myrCells are high quality human iPSC-derived cells to be used in drug discovery and development.
myrCells are reprogrammed from human iPSC lines, cultured in defined proprietary serum-free cell culture conditions. The use of myrCells as an in vitro research model provides a major advantage over primary cells as they provide a continuous source of cells from the same genetic background for use in multiple experiments.
They can be used use in functional screening, drug validation, toxicity testing, and many other applications. myrCells are available as deeply characterized wild-type and disease-specific cells, with reporter-enabled models for defined biological questions and quantitative assays
Every batch is defined and characterized for identity & differentiation quality; purity , contamination & Viability. Each released LOT of myrCell comes with a Certificate of Analysis and Handling Instructions.
myrCell-Cardio
Human iPSC-derived cardiomyocytes
(cryopreserved)
myrCell-Skeletal
Human iPSC-derived Skeletal myocytes
(cryopreserved)
myrCell-Stromal
Human iPSC-derived Fibroblasts
(cryopreserved)
Choose the biology. Add the readout.
WT
Wild-type
STANDARD MODELS
WT Cardiomyocytes
WT Skeletal myocytes
WT Stroma cells
REPORTER MODELS
Engineered for live, quantitative readouts
ColPaint
Luciferase
Disease –
Patient Derived
Patient-specific mutations
STANDARD MODELS
Patient-derived iPS differentiated cardiomycytes, skeletal myocytes, stromal cells.
REPORTER MODELS
Engineered for live, quantitative readouts
Selected patient-derived disease lines are also available in reporter backgrounds.
Disease CRISPR
engineered
Isogenic disease models on demand
STANDARD MODELS
CRISPR engineered mutation in isogenic background for differentiated cardiomyocytes, skeletal myocytes, stromal cells.
REPORTER MODELS
Engineered for live, quantitative readouts
Mutation + SarcPaint / ColPaint / Luciferase
Custom reporter disease models can be generated on demand.
Looking for a specific mutation or custom model?
Reporter models
Make biology visible.
Engineered reporter lines turn key cellular and tissue processes into quantitative, live readouts, enabling defined biological questions to be studied quantitatively and longitudinally with high-content and high-throughput screening (HTS) assays.
SarcPaint
ACTN2-Citrine Fluorescence
Visualize sarcomeres.
Measure function.
Sarcomere organization
Assess structuaral maturation
Functional response
Measure contractile behaviour
Longitudinal phenotyping
Monitor dynamic changes over time
Track cardiomyocyte structural injury and recovery*
ColPaint
Col1A2-Citrine Flurorescence
Visualize collagen.
Track remodelling.
Collagen production
Quantify matrix deposition
Matrix remodelling
Study fibrotic processes
Fibrotic response
Evaluate anti-fibrotic compounds
Track spatial remodeling of the ECM
Luciferase
Firefly Luciferase
Track cells over time.
Cell tracking
Monitor cell location and expansion
Survival and viability
Quantify cell persistence
Longitudinal tracking
Non-invasive, real-time readout
